Even the AstraZeneca/Oxford’s adenoviral vaccine is no longer effective against the SARS-CoV-2 strain carrying the E484K mutation in the real-wold. The Novavax and Johnson & Johnson vaccines are less effective against the E484K mutation in humans. Based on lab settings (not confirmed in humans yet), the Pfizer-BioNTech and Moderna mRNA vaccines may also be less effective at fending off this strain.